The Anatomical Architecture of the Junction between the Great Cerebral Vein and the Straight Sinus in Correlation to the Physiological and Biochemical Impact on Multiple Sclerosis Subtypes and Disease Progression (A Review Article)
Abstract
Multiple Sclerosis (MS) is a debilitating autoimmune disorder, characterized by damage to the
white matter of the central nervous system. Studies suggest a relationship between impaired
cerebral venous blood flow and progressive destruction of white matter in the CNS. Altered
cerebral venous architecture is a possible mechanism that may contribute to a compromised
venous blood flow pattern in MS patients. Natural variations at junction located between the
great cerebral vein (GCV) and the straight sinus (Ss) located within the cerebral venous drainage
system can potentially exacerbate MS progression. Recent data indicates that abnormal cerebral
venous hemodynamics contributes to the pathophysiology observed in MS through an unknown
mechanism that increases hydraulic resistance.
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